How 5 o’clock® Compares to Popular Liver Supplements
Based on each brand’s published label and listing information, checked October 2026.
| 5 o’clock® Liver & Energy Support† | Bronson Milk Thistle & Dandelion | Nature’s Craft Liver Cleanse Detox & Repair | Hepagard Liver Support | Cheers Restore | |
|---|---|---|---|---|---|
| Form | Tablet | Capsule | Capsule | Capsule | Capsule |
| Serving size | 1 tablet | 1 capsule | 2 capsules | 1–2 capsules | 3 capsules |
| Bottle size | 30 tablets (30 days) | 120 capsules | 60 capsules (30 servings) | 30 capsules (15–30 days) | 36 capsules (12 doses) |
| List price* | $31.25 | $9.99 | $22.99 | $39.95 | $34.99 |
| Cost per serving* | ≈ $1.04 | ≈ $0.08 | ≈ $0.77 | ≈ $1.33–$2.66 | ≈ $2.92 |
| When to take | Morning, or 1 hour before drinking | Daily | Daily | Daily | After drinking / before bed |
| Milk thistle (silymarin) | ✓ 200 mg extract, standardized to 80% silymarin | ✓ 111 mg of 9:1 extract | ✓ | ✓ | ✓ |
| NAC (N-acetylcysteine) | ✓ 600 mg | — | — | ✓ | — (uses 450 mg L-cysteine) |
| All 8 B vitamins | ✓ 100% DV each B1 1.2 mg · B2 1.3 mg · B3 16 mg NE · B5 5 mg · B6 1.7 mg · B7 30 mcg · B9 400 mcg · B12 2.4 mcg | — | — | — | B12 only |
| Zinc | ✓ 11 mg as zinc gluconate (100% DV) | — | — | — | — |
| Other key ingredients | — | Dandelion root | Dandelion root, artichoke, chanca piedra, berberine, ginger, beetroot | Dandelion root, artichoke leaf, choline bitartrate | 1,000+ mg DHM (vine tea), ginger |
| Sugar / flavor | Sugar-free, flavorless | — | — | — | — |
*Prices are typical U.S. listed prices as of October 2026 and change often; check the retailer for current pricing. “—” means the ingredient is not listed in that product’s published formula or the information was not available. All trademarks belong to their respective owners; their use here identifies products only and implies no affiliation or endorsement. Hepagard serving range reflects the manufacturer’s directions (1–2 capsules daily); its ingredient amounts are not published. Comparison is based on label contents only and is not a claim that any product is more effective than another.
†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Frequently Asked Questions
How does 5 o’clock® compare to other popular liver supplements?
5 o’clock® is the only product in this comparison that combines milk thistle extract (200 mg, standardized to 80% silymarin), NAC (600 mg), all eight B vitamins at 100% DV, and zinc (11 mg) in one tablet a day. Bronson, Nature’s Craft, Hepagard and Cheers Restore each contain milk thistle, but none of them list all eight B vitamins and zinc.
How is 5 o’clock® different from Bronson Milk Thistle & Dandelion?
Bronson contains 111 mg of a 9:1 milk thistle extract plus dandelion root in one capsule. It does not list NAC, B vitamins or zinc. 5 o’clock® adds 600 mg NAC, all eight B vitamins and zinc. Bronson costs less per serving (about $0.08 vs. about $1.04).
How is 5 o’clock® different from Cheers Restore?
Cheers Restore is taken as 3 capsules after drinking and is built around DHM (vine tea), with 450 mg L-cysteine and vitamin B12. 5 o’clock® is one tablet taken in the morning or 1 hour before drinking, with 600 mg NAC, all eight B vitamins and zinc. Cheers costs about $2.92 per serving; 5 o’clock® costs about $1.04.
How is 5 o’clock® different from Hepagard Liver Support?
Both contain milk thistle and NAC. Hepagard also lists dandelion root, artichoke leaf and choline bitartrate, taken as 1–2 capsules daily, but does not publish its ingredient amounts. 5 o’clock® publishes every amount and adds all eight B vitamins and zinc.
How is 5 o’clock® different from Nature’s Craft Liver Cleanse Detox & Repair?
Nature’s Craft combines milk thistle with dandelion root, artichoke, chanca piedra, berberine, ginger and beetroot in a 2-capsule serving. It does not list NAC, B vitamins or zinc.
How do I take 5 o’clock®?
Take one tablet in the morning or 1 hour before drinking. It is sugar-free and flavorless. 5 o’clock® is not a substitute for drinking responsibly.
Comparisons are based on each brand’s published label and listing information as of October 2026. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.